A 64 year – old lady underwent cataract surgery in the left eye for immature senile cataract with Intraocular Lens Implantation. Preoperatively her vision in the left eye was 6/60. Postoperatively on day 1 she had vision of 6/9 in her eye and she was comfortable. The third day she experienced pain, redness of eye and blurred vision. It increased by night and the next day she went for a check up. On examination the vision in her left eye was counting fingers 1 meter. Her left eye showed mild swelling of the eyelids, with marked redness of the eye. The eye showed intense inflammatory reaction with some pus formation in the Anterior Chamber. There was a very hazy view of the fundus.

Ultrasonography of the left eye showed vitreous echoes with intact retina. She was diagnosed to have Postoperative Endophthalmitis and underwent immediate vitreous tap with Intravitreal antibiotic injection left eye. She was also put on topical and systemic treatment. The gram stain and culture showed bacterial infection (gram positive bacillus) sensitive to antibiotics like vancomycin. She underwent repeat intravitreal antibiotic injection thrice and showed significant improvement in clearing up of inflammation and exudation. Her vision post treatment was 6/12. Prompt treatment saved the eye in this condition or else it would have been lost to infection.

A 59 - year old shopkeeper presented with severe pain, redness, discharge and loss of vision in the right eye of 2 days duration. He had undergone cataract surgery with Intraocular lens implantation right eye one week back. Second postoperative day he developed mild irritation in the eye that increased into severe pain by 2 days. He had shown to some local doctor who prescribed him systemic antibiotics but the patient had no relief. Ocular examination showed whitish exudates in the Anterior Chamber with no view of the pupil or the fundus.

Visual acuity was light perception only. Ultrasound of the right eye showed dense vitreous echoes. She was diagnosed to have Postoperative Endophthalmitis and underwent immediate Anterior core Vitrectomy with vitreous tap and intravitreal antibiotic injection. The gram staining and culture of vitreous sample showed bacterial infection. She underwent twice the intravitreal antibiotic injection. Thereafter it was seen that there were still lot of exudates in the vitreous cavity. So Pars Plana Vitrectomy was done to remove all the exudates followed by antibiotic injection. She needed 2 more intravitreal injections to quieten the eye. Subsequently her vision improved to 6/24.